Helps to support/promote healthy estrogen metabolism/balance.NPN: 80069955
Indole-3-Carbinol (NPN 80069955), 60 vcaps

Highlights
1. Pure Indole-3-carbinol (I3C) 400 mg per capsule
2. Helps to support/promote healthy estrogen metabolism/balance.
3. Powerful antioxidant activity
4. Anti-inflammatory effects
5. Beneficial phytochemical found in cruciferous vegetables

What is Indole-3-Carbinol?
• Indole-3-carbinol (I3C) is a phytochemical derived from the enzymatic breakdown of glucobrassicin, a compound found in cruciferous vegetables such as brussels sprout, cabbage, broccoli, mustard greens, kale, and cauliflower (1).
• When raw cruciferous vegetables are chopped or chewed, glucobrassicin in the damaged plant cells breakdown by plant enzyme (myrosinase) in the stomach and small intestine (2).
• However, when cruciferous vegetables are cooked, the generation of I3C from glucobrassicin is prevented due to the inactivation of a plant enzyme. Thus, intact glucobrassicin is metabolized by bacterial myrosinase and I3C is produced in the large intestine (2).

Key Benefits of Indole-3-Carbinol
1. Estrogen balance
Indole-3-carbinol helps to promote healthy estrogen metabolism and balance by modulating the estrogen regulation cycles in several ways to decrease the risk of certain tumors (3). A study found that oral supplementation with 300-400 mg/d of I3C has significantly increased urinary 2-hydroxyestrone (2OHE) levels known as a good estrogenic metabolite (4).

2. Anti-inflammatory effects
Indole-3-carbinol helps reduce the production of inflammatory molecules, such as cytokines and prostaglandins because I3C is associated with the modulating inflammatory mediators and several signaling pathways involved in inflammation. A study showed that inflammation and oxidative damage play critical roles in cardiovascular disease and I3C is a potent cardioprotective phytochemical due to its anti-inflammatory and antioxidant effects on the cardiovascular mechanism (5).

3. Powerful antioxidant activity
Oxidative stress is known to contribute to the development of chronic diseases such as cardiovascular disease, neurodegenerative disorders, and certain cancers. Indole-3-carbinol is a powerful antioxidant reducing oxidative stress from free radicals due to the free radical neutralizing effects and can protect body cells from the oxidative reactions. By reducing oxidative stress, I3C may have potential benefits in promoting overall health and reducing the risk of chronic diseases (5).

4. Modulation of cell-signaling pathways
In cancer cells, the cell cycles including cell proliferation, apoptosis, migration, invasion, angiogenesis, and immunity are often uncontrolled. Indole-3-carbinol has positive effects on the cell-signaling pathways and its functions can support cellular health (6).

Cautions and Warnings

Consult a health care practitioner prior to use if you are taking medications or natural health products,if you are attempting to conceive, or if you have a liver disorder or symptoms of low estrogen(such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness or irregular menstruations).
If you develop liver-related symptoms or symptoms of low estrogen, discontinue use and consult a health care practitioner.To exclude the diagnosis of a serious cause of hormonal imbalance, consult a health care practitioner prior to use.

Contra-Indications

If you are pregnant or breastfeeding, do not use this product



References
1. Holst, B., & Williamson, G. (2004). A critical review of the bioavailability of glucosinolates and related compounds. Natural Product Reports, 21(3), 425–447

2. Barba, F. J., Nikmaram, N., Roohinejad, S., Khelfa, A., Zhu, Z., & Koubaa, M. (2016). Bioavailability of Glucosinolates and Their Breakdown Products: Impact of Processing. Frontiers in Nutrition (Lausanne), 3, 24–24.
3. Bell, M. C., Crowley-Nowick, P., Bradlow, H. L., Sepkovic, D. W., Schmidt-Grimminger, D., Howell, P., Mayeaux, E. J., Tucker, A., Turbat-Herrera, E. A., & Mathis, J. M. (2000). Placebo-Controlled Trial of Indole-3-Carbinol in the Treatment of CIN. Gynecologic Oncology, 78(2), 123–129.
4. Higdon, J. V., Delage, B., Williams, D. E., & Dashwood, R. H. (2007). Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacological Research, 55(3), 224–236.
5. Prado, N. J., Ramirez, D., Mazzei, L., Parra, M., Casarotto, M., Calvo, J. P., Cuello carrión, D., Ponce Zumino, A. Z., Diez, E. R., Camargo, A., Manucha, & Walter, M. (2022). Anti-inflammatory, antioxidant, antihypertensive, and antiarrhythmic effect of indole-3-carbinol, a phytochemical derived from cruciferous vegetables. Heliyon, 8(2), e08989–e08989.
6. Licznerska, B. E., Szaefer, H., Murias, M., Bartoszek, A., & Baer-Dubowska, W. (2013). Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,3?-diindolylmethene in human breast epithelial cell lines. European Journal of Nutrition, 52(5), 1483–1492.

Adults: 1 Capsule 1 time per day

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